| Target antigen: |
HOXA1 |
| Clonality: |
Polyclonal antibody |
| Clone: |
Polyclonal antibody |
| Raised in: |
rabbit |
| Type of the antibody: |
IgG polyclonal antibody |
| Product form: |
freeze-dried |
| Reacts with species:: |
human Predicted to work with: mouse, rat |
| Analyses: |
WB |
| Immunogen: |
A synthetic peptide corresponding to a sequence at the N-terminus of human HOXA1(24-39aa SARAYPSDHRITTFQS), different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids. |
| Product configuration: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Purification: |
Immunogen affinity purified. |
| Solubilization: |
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml |
| Storage condtions: |
Keep the HOXA1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way. |
| Tips: |
The HOXA1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics. |
| Background: |
HOXA1(HOMEOBOX A1), also called HOMEOBOX 1F, is a protein that in humans is encoded by the HOXA1 gene. In PA-1 teratocarcinoma cells, HOXA1 was induced by retinoic acid earlier than other HOXA cluster genes. The HOXA1 gene is mapped on 7p15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. A common polymorphism in the HOXA1 gene is associated with a susceptibility to autism spectrum disorder. Three-dimensional reconstructions of Hoxa1 -/- rhombencephalon revealed that it bears only 5 rhombomeric structures instead of the normal 7. A single maternal administration of a low dose of the vitamin A metabolite retinoic acid was sufficient to compensate the requirement for Hoxa1 function in Hoxa1-deficient mice. |
| Related articles: |
1. Apiou, F., Flagiello, D., Cillo, C., Malfoy, B., Poupon, M.-F., Dutrillaux, B. Fine mapping of human HOX gene clusters. Cytogenet. Cell Genet. 73: 114-115, 1996. 2. Bosley, T. M., Alorainy, I. A., Salih, M. A., Aldhalaan, H. M., Abu-Amero, K. K., Oystreck, D. T., Tischfield, M. A., Engle, E. C., Erickson, R. P. The clinical spectrum of homozygous HOXA1 mutations. Am. J. Med. Genet. 146A: 1235-1240, 2008. 3. Ingram, J. L., Stodgell, C. J., Hyman, S. L., Figlewicz, D. A., Weitkamp, L. R., Rodier, P. M. Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders. Teratology 62: 393-405, 2000. |
| Gene Name: |
HOXA1 |
| Protein Name: |
Homeobox protein Hox-A1 |
| Gene Full Name: |
homeobox A1 |
| Synonyms: |
BSAS antibody|Homeo box A1 antibody|Homeobox 1F antibody|Homeobox A1 antibody|Homeobox protein Hox A1 antibody|Homeobox protein Hox-1F antibody|Homeobox protein Hox-A1 antibody|Hox 1.6 like protein antibody|Hox 1F antibody|HOX A1 antibody|HOX A1 homeodomain protein antibody|Hox-1F antibody|HOX1 antibody|HOX1F antibody|hoxa1 antibody|hoxb1b antibody|HXA1_HUMAN antibody|Lab like protein antibody|MGC45232 antibody |
| Uniprot ID: |
P49639 |
| Properties: |
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. |
| French translation: |
anticorps |